“POC bioprocessing is the next big thing,” says Govind Rao, PhD, director of the center for advanced sensor technology at the University of Maryland, Baltimore County, who looked at the potential benefits in a recent paper.

The move to Bioprocessing 4.0 depends heavily on advancing sensor technology. Only then can one accurately monitor and control biochemical reactions occurring in living cells. At the University of Maryland, Baltimore County (UMBC), Govind Rao, PhD, professor of chemical, biochemical, and environmental engineering, and director of the center for advanced sensor technology (CAST), and his colleagues develop new sensors that help bioprocessors move from batch to continuous processing. One of the key elements to monitor is oxygen.

“Oxygen is the critical metabolic requirement for aerobic cells in culture and is the hardest to supply to cells due to its low solubility,” Rao explained. “Consequently, monitoring its presence is critical.”

Optical sensors offer promise in this area for oxygen and more. When asked about the most important recent advance in optical sensors that can be used in bioprocessing, Rao said that it’s “the ability to monitor multiple parameters in a non-invasive manner.”

Although research on optical sensors plays a fundamental role in their development, bioprocessors look for technology that can go into manufacturing facilities. That’s just what Rao develops. “All our sensors are designed for commercial application and in fact several are on the market,” he said

BALTIMORE SUN |

SEP 08, 2020 AT 3:35 PM