Graduate student Lauren Schoukroun-Barnes and undergraduate Ethan Glaser in the White Group publish their recent findings on heterogeneous sensor surfaces in Langmuir. The students used aptamer-based sensors achieve detection of analytes through a conformation change to develop a general method to predictably tune the sensitivity and linear range of electrochemical sensors using varying length aptamers (small single-stranded nucleic acids that fold into a well-defined three-dimensional structure). They demonstrated that mixtures of modified sequences can be used to tune the affinity, dynamic range, and sensitivity of the resulting sensors.