Researcher of the Week: Ugonna Mbaekwe

Tue, 14 Feb 2017 15:43:45 -0500
abrcms, biological, research, sciences, statistics

She is an a Biological Sciences major with a minor in Statistics. She was also a presenter at the Annual Biomedical Research Conference for Minority Students (ABRCMS) in 2016. Her project focused on measuring the binding interaction between small molecule ligands and the Core Encapsidation Signal of HIV-1 RNA as a potential drug target. Her future goal will to include obtaining her MD/PhD. She would like to open her own research lab, or have a teaching position at a university or be a clinical researcher. In her free time she is a member of the UMBC gospel choir and Learning Assistant for Biology 141.

Ugonna's research will focus on understanding how and in which orientation certain classes of ligands bind to the recently determined CES structure. Human Immunodeficiency Virus Type 1 (HIV-1) has become a worldwide epidemic with a high rate of infection. HIV attacks and destroys the infection-fighting CD4 cells of the immune system. Without treatment, HIV can gradually destroy the immune system and advance to AIDS, Acquired Immunodeficiency Syndrome. The purpose of this project is to develop therapeutics that target functional RNA elements within the highly-conserved 5′-untranslated region (UTR). The core encapsidation signal (CES) was identified as a minimal region within the 5’- UTR that is independently capable of directing the packaging of the virus’s unspliced dimeric genome.

Read more about her research here…