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<News hasArchived="true" page="133" pageCount="1243" pageSize="10" timestamp="Mon, 11 May 2026 14:03:54 -0400" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts.xml?mode=activity&amp;page=133">
  <NewsItem contentIssues="true" id="134461" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134461">
    <Title>PhD defense: Michael Tope, 2-4pm 8/16, ITE325</Title>
    <Body>
      <![CDATA[
          <div class="html-content"><span><h5><span>Ph.D. Dissertation Defense</span></h5>
          <br><h4><span>Near Optimal Sampling to Discover and Bound the Communication Rate of a Discrete Memoryless Channel</span></h4>
          <h4><span>Michael Tope</span></h4>
          <br><p><span><strong>Date</strong></span><span><strong>: </strong>August 16, 2023 at 2:00pm -- 4:00pm EDT</span></p>
          <p><span><strong>Location</strong></span><span><strong>:</strong> ITE 325B conference room or <a href="https://umbc.webex.com/meet/mtope1" rel="nofollow external" class="bo">Webex</a></span></p>
          <p><span><strong>Committee</strong></span><span><strong>:</strong> </span><span>Drs. Joel Morris (Chair/Advisor), </span><span>Tulay Adali (Co-Chair), </span><span>E. F. Charles LaBerge, </span><span>Christopher Marron, </span><span>Anindya Roy</span></p>
          <br><p><span>The aim of this research is to introduce, develop and evaluate active learning algorithms that provide near-optimal high-probability bounds on the channel capacity across a discrete memoryless channel (DMC), where the only information about the channel internals (i.e., the channel law) is from a set of observed input-output sample pairs (i.e., channel probes).   Channel capacity is the maximum rate (on average for each value sent into the channel) at which information can flow across the channel with an arbitrarily low error rate.</span></p>
          <p><span>Extending results on the discrete memoryless compound channel, which is comprised of deterministic constraints on the channel law uncertainty, we first develop an offline algorithm to process an observed set of N input-output sample pairs (probes) to compute lower and upper bounds on channel capacity (such that the bounds hold with high probability).  A key ingredient of this result is our new probability approximately correct (PAC) sublevel set bound that improves the convergence rate of Sanov's Theorem from O(log(N)/N) to O(log(log(N)/N) (where the convergence rate is the 'big Oh' Bachmann-Landau limiting behavior).  The experimental (simulation) results match the analytical results.</span></p>
          <p><span>Adapting techniques from pure-exploration multi-arm bandit problems, we further develop an online algorithm aimed at minimizing the sample complexity (i.e., the number of channel probes or samples of the DMC) required to establish a lower-bound channel rate RL that satisfies several stopping criteria, where the lower bound rate RL approaches the channel capacity with high probability.  We show that if the sample complexity of any optimal online algorithm (including a non-feasible clairvoyant algorithm that is given side information to simplify the analysis) is O(N) samples, then our online algorithm requires less than O(N*log(log(N))) sequential channel probes. Thus, we prove that our algorithm is within a sub-logarithmic factor of optimal (i.e. near optimal).</span></p>
          <p><span>The results of this research may provide a deeper general understanding of active machine learning algorithms.</span></p>
          <p><span><br></span></p>
          <p><img src="https://www.csee.umbc.edu/wp-content/uploads/sites/659/2023/07/channel_rate_discovery.jpg" style="max-width: 100%; height: auto;"></p></span></div>
      ]]>
    </Body>
    <Summary>Ph.D. Dissertation Defense   Near Optimal Sampling to Discover and Bound the Communication Rate of a Discrete Memoryless Channel  Michael Tope   Date: August 16, 2023 at 2:00pm -- 4:00pm EDT...</Summary>
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    <PostedAt>Mon, 31 Jul 2023 09:41:38 -0400</PostedAt>
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  <NewsItem contentIssues="true" id="134459" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134459">
  <Title>CodePath's no-cost remote Fall 2023 courses</Title>
  <Tagline>Apply by August 20</Tagline>
  <Body>
    <![CDATA[
    <div class="html-content">
    <img src="https://www.csee.umbc.edu/wp-content/uploads/sites/659/2023/07/codepath23.jpg" style="max-width: 100%; height: auto;"><div><br></div>
    <div><br></div>
    <div>
    <p><strong>CodePath's no-cost remote Fall 2023 courses</strong></p>
    <p><span>Applications are now open for CodePath's no-cost remote Fall 2023 courses!  <a href="https://www.codepath.org/courses" rel="nofollow external" class="bo"><strong>Apply</strong></a> by August 20, 2023.</span></p>
    <p><span><br></span></p>
    <p><span>This fall, <a href="https://www.codepath.org/" rel="nofollow external" class="bo"><strong>CodePath</strong></a> is offering a diverse range of courses designed to equip students with valuable skills for a successful tech career. Here are the courses available next semester:</span></p>
    <p><a href="https://umbc.us14.list-manage.com/track/click?u=e4249927f59897e63ea252de0&amp;id=725781dafb&amp;e=cdec89a9d4" rel="nofollow external" class="bo"><span><strong>Android Development in Kotlin</strong></span></a><span><strong>:</strong> Throughout this course, students will have the opportunity to plan, build, and test a fully-functional Android app using Kotlin. By the end of the course, students will gain proficiency in Android app development.</span></p>
    <p><a href="https://umbc.us14.list-manage.com/track/click?u=e4249927f59897e63ea252de0&amp;id=d7124406b8&amp;e=cdec89a9d4" rel="nofollow external" class="bo"><span><strong>iOS Mobile Development</strong></span></a><span><strong>: </strong>In this course, students will plan, build, and test a fully-functional iOS app. They will learn the ins and outs of iOS development, empowering them to create engaging mobile experiences.</span></p>
    <p><a href="https://umbc.us14.list-manage.com/track/click?u=e4249927f59897e63ea252de0&amp;id=b5c6bef305&amp;e=cdec89a9d4" rel="nofollow external" class="bo"><span><strong>Cybersecurity</strong></span></a><span><strong>: </strong>This course introduces students to the fundamentals of cybersecurity, covering common application vulnerabilities and attacks. Originally designed in collaboration with Meta, this course provides a comprehensive understanding of the cybersecurity landscape.</span></p>
    <p><a href="https://umbc.us14.list-manage.com/track/click?u=e4249927f59897e63ea252de0&amp;id=5bf02cff9c&amp;e=cdec89a9d4" rel="nofollow external" class="bo"><span><strong>Web Development</strong></span></a><span><strong>: </strong>Students will embark on a journey to design and create their own websites inspired by popular sites they already know and love. Starting with the structure and styling, students will learn to add interactive elements like videos, forms, and animations to bring their websites to life.</span></p>
    <p><span>CodePath's courses are developed and taught by seasoned software engineers who are deeply knowledgeable about industry best practices. We invite students to dream big, think differently, and unlock the doors to a successful tech career.</span></p>
    <p><a href="https://www.codepath.org/courses" rel="nofollow external" class="bo"><strong>Apply</strong></a><span> by August 20, 2023.</span></p>
    </div>
    </div>
]]>
  </Body>
  <Summary>CodePath's no-cost remote Fall 2023 courses  Applications are now open for CodePath's no-cost remote Fall 2023 courses!  Apply by August 20, 2023.     This fall, CodePath is offering a diverse...</Summary>
  <Website>https://www.codepath.org/</Website>
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  <PostedAt>Sun, 30 Jul 2023 21:27:10 -0400</PostedAt>
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  <NewsItem contentIssues="true" id="134445" important="true" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134445">
  <Title>Interested in Entrepreneurship or Nonprofit Leadership?</Title>
  <Tagline>Apply to the Shattuck Intern Program for Entrepreneurship!</Tagline>
  <Body>
    <![CDATA[
    <div class="html-content">
    <p><strong>Do you have an interest in Entrepreneurship or </strong><strong>becoming a Nonprofit Leader or Social Entrepreneur?</strong></p>
    <p><strong>Are you ready to intern within a Start-up, Nonprofit or Social Venture?</strong><br>
      <br><strong>
    If yes, apply to the Shattuck Family Internship Program for Entrepreneurship Innovation and Social Change for this Fall.</strong><br>
      <br>
    The Shattuck Family Internship Program for Entrepreneurship Innovation 
    and Social Change prepares UMBC students for the rigors and rewards of 
    entrepreneurship and social innovation.  This program funds students from diverse backgrounds in mentored 
    internships to better prepare them to launch for-profit ventures or 
    nonprofits.<br>
    </p>
    <p>Internships last one semester (15 weeks) and students will work on 
    average, 8 to 10 hours per week.  Students receive a stipend of $2,000 
    toward their compensation.<br>
      <br>
      <strong>DEADLINE TO APPLY: </strong> Monday, August 7<br>
      <br>
      <strong>Why Participate?</strong><br>
    - Earn a stipend of $2,000 plus an opportunity to potentially earn credit<br>
    - Gain valuable experience in your career field by interning 120 hours over the course of the semester (8-10 hours per week)<br>
    - Be exposed to the knowledge, skills, and mindset required to successfully launch and manage a growing business/nonprofit<br>
    - Apply classroom knowledge in a realistic work environment and apply lessons learned in the workplace to academic coursework<br>
      <br>
      <strong>TO APPLY:</strong><br>
    Interested students are asked to submit a Resume and a Cover Letter via <a href="https://app.joinhandshake.com/edu/jobs/8065906" rel="nofollow external" class="bo">HANDSHAKE</a> answering the following questions:<br>
    Discuss your interest in both entrepreneurship and this intern program. 
     What has been your entrepreneurial involvement thus far such as 
    coursework, seminars, etc. (if applicable)?  What type of start-up or 
    nonprofit would you like to intern for and why?  If you already have a 
    nonprofit or start-up in mind, please also share.<br>
      <br>
      <strong>REQUIREMENTS:</strong>  Open to ALL Majors, FIVE intern offers will be extended through this program this Fall 2023 semester.<br>
      <br>
    Your Resume and Cover Letter can be submitted via Handshake here- <a href="https://app.joinhandshake.com/edu/jobs/8065906" rel="nofollow external" class="bo">https://app.joinhandshake.com/edu/jobs/8065906</a><br>
      <br>
      <strong>DEADLINE TO APPLY:</strong>  Monday, August 7</p>
    </div>
]]>
  </Body>
  <Summary>Do you have an interest in Entrepreneurship or becoming a Nonprofit Leader or Social Entrepreneur?   Are you ready to intern within a Start-up, Nonprofit or Social Venture?      If yes, apply to...</Summary>
  <Website>https://app.joinhandshake.com/edu/jobs/8065906</Website>
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  <PostedAt>Fri, 28 Jul 2023 11:01:09 -0400</PostedAt>
  <EditAt>Fri, 28 Jul 2023 11:33:01 -0400</EditAt>
</NewsItem>
  <NewsItem contentIssues="true" id="134360" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134360">
  <Title>New i3b myUMBC Pages!</Title>
  <Tagline>Where to find the additional i3b myUMBC pages</Tagline>
  <Body>
    <![CDATA[
    <div class="html-content">
    <span>Hello Mosaic Community Members!</span><div><br></div>
    <div>All of us at i3b are hoping that you are finding rest and peace during these summer months. You may have noticed that the group page that served as the i3b group page has reverted back to its original owner, <a href="https://my3.my.umbc.edu/groups/themosaic" rel="nofollow external" class="bo">The Mosaic: Center for Cultural Diversity</a>. In an effort to improve our targeted engagement, data, and assessment, our department has made the decision to create individual myUMBC pages for each center and the i3b department. Below is the list of our new pages:</div>
    <div>
    <ul>
    <li><a href="https://my3.my.umbc.edu/groups/i3b" rel="nofollow external" class="bo">Initiatives for Identity, Inclusion &amp; Belonging (i3b)</a></li>
    <li><a href="https://my3.my.umbc.edu/groups/thepridecenter" rel="nofollow external" class="bo">The Pride Center for LGBTQIA2+ Diversity (i3b)</a></li>
    <li><a href="https://my3.my.umbc.edu/groups/thegatheringspace" rel="nofollow external" class="bo">The Gathering Space for Spiritual Well-Being (i3b)</a></li>
    </ul>
    <div>We encourage you to follow the additional new pages if you wish to know more about our broader departmental events, resources, and communications. We ask for your patience as the pages are currently under construction. We expect to be fully up and running with all Fall 2023-related content by Friday, August 18th. </div>
    </div>
    <div><br></div>
    <div>As we continue to build out our resources we also ask for you to follow our Linktree pages and i3b Instagram linked below:</div>
    <div><ul>
    <li><a href="https://linktr.ee/umbci3b" rel="nofollow external" class="bo">Linktree: Initiatives for Identity, Inclusion &amp; Belonging (i3b)</a></li>
    <li><a href="https://linktr.ee/umbcpridecenter" rel="nofollow external" class="bo">Linktree: The Pride Center for LGBTQIA2+ Diversity with Initiatives for Identity, Inclusion &amp; Belonging (i3b)</a></li>
    <li><a href="https://www.instagram.com/umbci3b/" rel="nofollow external" class="bo">Instagram: Initiatives for Identity, Inclusion &amp; Belonging (i3b)</a></li>
    </ul></div>
    <div>We appreciate your patience as we integrate these updates and onboard new staff. If you have any questions please do not hesitate to contact us at <a href="mailto:i3b@umbc.edu" rel="nofollow external" class="bo">i3b@umbc.edu</a>. </div>
    <div><br></div>
    <div>- Angelina R. Jenkins, Assistant Director on behalf of The Mosaic team &amp; i3b </div>
    </div>
]]>
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  <Summary>Hello Mosaic Community Members!    All of us at i3b are hoping that you are finding rest and peace during these summer months. You may have noticed that the group page that served as the i3b group...</Summary>
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  <Sponsor>The Mosaic: Center for Cultural Diversity (i3b)</Sponsor>
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  <PostedAt>Fri, 21 Jul 2023 10:19:21 -0400</PostedAt>
  <EditAt>Fri, 21 Jul 2023 11:47:27 -0400</EditAt>
</NewsItem>
  <NewsItem contentIssues="false" id="134335" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134335">
  <Title>CBEE alumnus - FY24 president of Society of Women Engineers</Title>
  <Tagline>Alexis (Hillock) McKittrick, '01</Tagline>
  <Body>
    <![CDATA[
    <div class="html-content">
    <strong>Congratulations to Dr. Alexis (Hillock) McKittrick, '01 on her role as FY24 Society of Women Engineers (SWE) President </strong><div><br></div>
    <div>
    <div>Alexis McKittrick, Ph.D., a Society of Women Engineers 20-plus year and life member, has served as a volunteer leader in the organization for more than 15 years, holding roles that span all facets of the Society. Prior to being elected president, Dr. McKittrick served as president-elect and spent two terms on SWE’s board of directors, including serving as secretary and leading the senate as speaker. Highlights from her other SWE leadership roles include chairing two committees; serving on two governance task forces; and serving as governor of the Mid-Atlantic Region.</div>
    <div><br></div>
    <div>Dr. McKittrick is currently a program manager in the U.S. Department of Energy (DOE) Geothermal Technologies Office. She serves on the SWE board of directors in her personal capacity. Prior to joining the DOE, Dr. McKittrick served as a senior researcher at the IDA Science and Technology Policy Institute in Washington, D.C., where she conducted nonpartisan research and analysis for the White House Office of Science and Technology Policy and various federal agencies. She also worked in the U.S. Environmental Protection Agency’s Climate Change Division, focusing on greenhouse gas analysis and policy for the oil and gas, chemicals, and semiconductor sectors.</div>
    <div><br></div>
    <div>Dr. McKittrick holds a Ph.D. in chemical engineering from the Georgia Institute of Technology and a B.S. in chemical engineering from the University of Maryland, Baltimore County, where she was a Meyerhoff Scholar.</div>
    <div><br></div>
    <div>In 2014, she was presented with the D.C. Council of Engineering and Architectural Societies’ Young Engineer of the Year Award and received SWE’s Emerging Leader Award in 2019.</div>
    </div>
    <div><br></div>
    <div><strong>Learn more: </strong></div>
    <div><a href="https://alltogether.swe.org/2023/07/diverse-podcast-swe-presidents/" rel="nofollow external" class="bo">https://alltogether.swe.org/2023/07/diverse-podcast-swe-presidents/</a></div>
    </div>
]]>
  </Body>
  <Summary>Congratulations to Dr. Alexis (Hillock) McKittrick, '01 on her role as FY24 Society of Women Engineers (SWE) President      Alexis McKittrick, Ph.D., a Society of Women Engineers 20-plus year and...</Summary>
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  <Tag>alumni</Tag>
  <Tag>fall-2023</Tag>
  <Group token="cbee">Chemical, Biochemical and Environmental Engineering</Group>
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  <PostedAt>Wed, 19 Jul 2023 12:16:33 -0400</PostedAt>
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  <NewsItem contentIssues="false" id="134330" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134330">
  <Title>TIME SENSITIVE:  Student Worker Position Available!</Title>
  <Tagline>Learn About the Maryland Early Childhood Leadership Program</Tagline>
  <Body>
    <![CDATA[
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    <div>
    <span>The </span><span>Maryland Early Childhood Leadership Program (MECLP) is seeking a student worker to support its program, which is based out of The Shriver Center. The position is a 12-month position that would begin in late August. </span>
    </div>
    <div><span><br></span></div>
    <div>
    <span>As mentioned in the attached position description and application, applicants should be a Junior or <span>higher-level undergraduate, or graduate level student, (graduate student is preferred) with a comprehensive knowledge of social</span></span><span> </span><span>media platforms, Google Apps, IoT devices, and design software. Students from Education, Psychology, Public Policy, and Sociology Departments are preferred. </span>
    </div>
    <div><br></div>
    <div>The application includes a few short essay questions and suggested interview times/dates, which would be held virtually.  Should none of those dates/times work, share some other options when you submit your application and resume to Louise Corwin,<span> Chair of the MECLP Advisory Committee, </span>at <a href="mailto:lcorwin@umbc.edu" rel="nofollow external" class="bo">lcorwin@umbc.edu</a>.<span> </span>
    </div>
    <div><br></div>
    <div>
    <span>If you have any questions, reach out to Louise at </span><a href="mailto:lcorwin@umbc.edu" rel="nofollow external" class="bo">lcorwin@umbc.edu</a>.</div>
    <div><br></div>
    <div>More info about MECLP can be found at </div>
    </div>
]]>
  </Body>
  <Summary>The Maryland Early Childhood Leadership Program (MECLP) is seeking a student worker to support its program, which is based out of The Shriver Center. The position is a 12-month position that would...</Summary>
  <Website>https://shrivercenter.umbc.edu/</Website>
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  <Sponsor>The Shriver Center</Sponsor>
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  <PostedAt>Tue, 18 Jul 2023 21:25:24 -0400</PostedAt>
</NewsItem>
  <NewsItem contentIssues="false" id="134322" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134322">
    <Title>Deadline Extended: Apply to be a CWIT Peer Mentor by 07/31!</Title>
    <Tagline>The application is still open for the 2023-2024 school year!</Tagline>
    <Body>
      <![CDATA[
          <div class="html-content">If you didn't get to apply to be a CWIT Peer Mentor by the 07/15 deadline, there's still time; we've extended our deadline to <strong>July 31!</strong><div><br></div>
          <div><strong>The application to be a CWIT Peer Mentor is <a href="http://https://docs.google.com/forms/d/e/1FAIpQLSfK0Qc__fpMz6S6iZfxtWVVfAaz2_4Ft6KwILMpb5_srvG7ZA/viewform?usp=sf_link" rel="nofollow external" class="bo">HERE</a>.</strong></div>
          <div><br></div>
          <div>CWIT Peer Mentors will help guide our new Scholars &amp; Affiliates through their first year of UMBC life, through support of their academic, professional and personal goals. </div>
          <div>Mentors will receive <strong>$150 in Retriever Dollars</strong> each semester.</div>
          <div><br></div>
          <div>A full breakdown of responsibilities and time commitments can be found on the application.</div>
          <div><br></div>
          <div>Feel free to contact Morgan Lovell at <u><a href="mailto:mlovell1@umbc.edu">mlovell1@umbc.edu</a></u> if you have any questions!</div>
          </div>
      ]]>
    </Body>
    <Summary>If you didn't get to apply to be a CWIT Peer Mentor by the 07/15 deadline, there's still time; we've extended our deadline to July 31!    The application to be a CWIT Peer Mentor is HERE.     CWIT...</Summary>
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    <PostedAt>Tue, 18 Jul 2023 09:58:26 -0400</PostedAt>
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  <NewsItem contentIssues="true" id="134285" important="true" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134285">
    <Title>Weekday Access Coming Fall 2023 - Route 40 Bus route</Title>
    <Tagline>New Update from UMBC Transit</Tagline>
    <Body>
      <![CDATA[
          <div class="html-content">
          <div><a href="https://my3.my.umbc.edu/groups/transit/posts/134283" rel="nofollow external" class="bo"><em>Click here to see the original post</em> </a></div>
          <div><br></div>
          <div>
          <div>Beginning in Fall 2023, UMBC Transit will provide weekday access to the Route 40/Ellicott City communities. Historically, this route had been a weekend-only route that accommodated shopping options for our students during the weekends. With an increased number of  Graduate and undergraduate students living in the Route 40 and Ellicott City community, the requests for weekday access have also grown.</div>
          <div><br></div>
          <div>This transportation route gives students a dependable means of getting to and from campus on weekdays and weekends. Along the way, you'll pass through a vibrant network of shopping centers, international markets, apartments, homes, and eateries.</div>
          <div><br></div>
          <div>In the coming weeks, Transit will publish this route's Fall 2023 schedule and other points of interest. In the meantime, you can <strong><a href="https://youtu.be/1VPAWrYcPAg" rel="nofollow external" class="bo">Ride Virtually Here</a>.</strong>
          </div>
          </div>
          </div>
      ]]>
    </Body>
    <Summary>Click here to see the original post       Beginning in Fall 2023, UMBC Transit will provide weekday access to the Route 40/Ellicott City communities. Historically, this route had been a...</Summary>
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    <Sponsor>Off-Campus Student Services</Sponsor>
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    <PostedAt>Thu, 13 Jul 2023 10:50:26 -0400</PostedAt>
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  <NewsItem contentIssues="false" id="134278" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134278">
    <Title>New Publication by CBEE Alumni</Title>
    <Tagline>Dr. Yun Jiao, PhD '21 Chemical and Biochemical Engineering</Tagline>
    <Body>
      <![CDATA[
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          <div>
          <strong>Dr. Yun Jiao</strong>, PhD '21 chemical and biochemical engineering, has a new paper, based on her doctoral research, "Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration", which was published in the ScienceAdvances.  </div>
          <div><br></div>
          <div>The article is available here:</div>
          <div><a href="https://www.science.org/doi/10.1126/sciadv.add1101" rel="nofollow external" class="bo">DOI: 10.1126/sciadv.add1101</a></div>
          <div><br></div>
          <div><h3>Abstract</h3></div>
          <p>Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (&gt;18 months old) and demonstrate that in comparison to young mice, one-third of old microglia are AF, characterized by profound changes in lipid and iron content, phagocytic activity, and oxidative stress. Pharmacological depletion of microglia in old mice eliminated the AF microglia following repopulation and reversed microglial dysfunction. Age-related neurological deficits and neurodegeneration after traumatic brain injury (TBI) were attenuated in old mice lacking AF microglia. Furthermore, increased phagocytic activity, lysosomal burden, and lipid accumulation in microglia persisted for up to 1 year after TBI, were modified by <em>APOE4</em> genotype, and chronically driven by phagocyte-mediated oxidative stress. Thus, AF may reflect a pathological state in aging microglia associated with increased phagocytosis of neurons and myelin and inflammatory neurodegeneration that can be further accelerated by TBI.</p>
          </div>
      ]]>
    </Body>
    <Summary>Dr. Yun Jiao, PhD '21 chemical and biochemical engineering, has a new paper, based on her doctoral research, "Brain injury accelerates the onset of a reversible age-related microglial phenotype...</Summary>
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    <PostedAt>Wed, 12 Jul 2023 12:17:39 -0400</PostedAt>
    <EditAt>Mon, 29 Apr 2024 11:53:44 -0400</EditAt>
  </NewsItem>
  <NewsItem contentIssues="false" id="134277" important="false" status="posted" url="https://dev.my.umbc.edu/groups/cwitaffiliates/posts/134277">
  <Title>New Publication by CBEE Alumni</Title>
  <Tagline>Dr. Michael H. Zhang, PhD '21</Tagline>
  <Body>
    <![CDATA[
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    <div>
    <strong>Dr. Michael H. Zhang</strong>, PhD '21 chemical and biochemical engineering has a new paper, based on his doctoral research, "Lipid–Polymer Hybrid Nanoparticles Utilize B Cells and Dendritic Cells to Elicit Distinct Antigen-Specific CD4+ and CD8+ T Cell Responses", which was published in the ACS Applied Bio Materials.  </div>
    <div><br></div>
    <div>The article is available here:</div>
    <div><a href="https://pubs.acs.org/doi/full/10.1021/acsabm.3c00229" rel="nofollow external" class="bo">https://pubs.acs.org/doi/full/10.1021/acsabm.3c00229</a></div>
    <div><br></div>
    <div><h3>Abstract</h3></div>
    <div><p>Antigen-presenting cells (APCs) are widely studied for treating immune-mediated diseases, and dendritic cells (DCs) are potent APCs that uptake and present antigens (Ags). However, DCs face several challenges that hinder their clinical translation due to their inability to control Ag dosing and low abundance in peripheral blood. B cells are a potential alternative to DCs, but their poor nonspecific Ag uptake capabilities compromise controllable priming of T cells. Here, we developed phospholipid-conjugated Ags (L-Ags) and lipid–polymer hybrid nanoparticles (L/P-Ag NPs) as delivery platforms to expand the range of accessible APCs for use in T cell priming. These delivery platforms were evaluated using DCs, CD40-activated B cells, and resting B cells to understand the impacts of various Ag delivery mechanisms for generation of Ag-specific T cell responses. L-Ag delivery (termed depoting) of MHC class I- and II-restricted Ags successfully loaded all APC types in a tunable manner and primed both Ag-specific CD8<sup>+</sup> and CD4<sup>+</sup> T cells, respectively. Incorporating L-Ags and polymer-conjugated Ags (P-Ag) into NPs can direct Ags to different uptake pathways to engineer the dynamics of presentation and shape T cell responses. DCs were capable of processing and presenting Ag delivered from both L- and P-Ag NPs, yet B cells could only utilize Ag delivered from L-Ag NPs, which led to differential cytokine secretion profiles in coculture studies. Altogether, we show that L-Ags and P-Ags can be rationally paired within a single NP to leverage distinct delivery mechanisms to access multiple Ag processing pathways in two APC types, offering a modular delivery platform for engineering Ag-specific immunotherapies.</p></div>
    </div>
]]>
  </Body>
  <Summary>Dr. Michael H. Zhang, PhD '21 chemical and biochemical engineering has a new paper, based on his doctoral research, "Lipid–Polymer Hybrid Nanoparticles Utilize B Cells and Dendritic Cells to...</Summary>
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  <PostedAt>Wed, 12 Jul 2023 12:13:10 -0400</PostedAt>
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